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© 2023 sanofi-aventis Canada Inc. All rights reserved.
MAT-CA-2300298
Last updated: 06/2023
Disease severity and eczema severity as measured by IGA and EASI, respectively
Efficacy results of DUPIXENT® in the AD-1526 Study at Week 16 (FAS)1,16†
Adapted from the Product Monograph.1
The long-term efficacy of DUPIXENT® in adolescent patients with moderate-to-severe AD who had participated in previous clinical trials of DUPIXENT® was assessed in an open-label extension trial (AD-1434).1
- Efficacy data from this trial suggests that clinical benefit provided at Week 16 was sustained through Week 52.
FAS: full analysis set
† FAS includes all subjects randomized.
‡ Responder was defined as a subject with IGA 0 or 1 (“clear” or “almost clear”) with a reduction of ≥2 points on a 0-4 IGA scale.1
§ Subjects who received rescue treatment or with missing data were considered as non-responders (59% in the placebo arm and 21% in the DUPIXENT® arm).1
Pruritus severity as measured by NRS
Pruritus NRS - LS mean change from baseline to Week 16 in the AD-1526 Study (FAS, +/- SE, other outcome)1,16†
Adapted from Simpson et al.3
Peak Pruritus NRS‡ (≥4-point improvement):
• 37% for DUPIXENT®
• 5% for Placebo
A significantly greater proportion of subjects randomized to DUPIXENT® achieved a rapid improvement in the pruritus NRS compared to placebo (defined as >4-point improvement as early as Week 4; nominal p<0.001).1
The proportion of subjects responding on the pruritus NRS continued to increase through the treatment period. The improvement in pruritus NRS occurred in conjunction with the improvement of objective signs of atopic dermatitis.1
LS: least squares; FAS: full analysis set; SE: standard error
† FAS includes all subjects randomized.
‡ Subjects who received rescue treatment or with missing data were considered as non-responders (59% and 21% in the placebo and DUPIXENT® arms, respectively).
Improvement shown in patient-reported outcomes – CDLQI and POEM
CDLQI - LS mean change from baseline to Week 16 in the AD-1526 Study (FAS, +/- SE, other outcome)1,16
Adapted from Simpson et al.3
POEM - LS mean change from baseline to Week 16 in the AD-1526 Study (FAS, +/- SE, other outcome)1,16
Adapted from Simpson et al.3
Patient-reported outcomes CDLQI and POEM were consistent with significant improvements observed in the physician-reported outcomes.1
A larger percentage of subjects randomized to placebo needed rescue treatment (topical corticosteroids, systemic corticosteroids, or systemic non-steroidal immunosuppressants) as compared to the DUPIXENT® group (59% and 21%, respectively).1
Disease severity and eczema severity as measured by IGA
IGA results of DUPIXENT® + TCS in the AD-1652 study at Week 16 (FAS, primary endpoint)1,18†
Adapted from the Product Monograph and Paller et al., 2020.1,18
* Nominal p-values.
The efficacy of DUPIXENT® + TCS in pediatric patients with moderate-to-severe AD who had participated in previous clinical trials of DUPIXENT® + TCS was assessed enrolled in an open-label extension trial (AD-1434).1
- Efficacy data from this trial suggests that the effect observed at Week 16 was consistent at Week 52.
FAS: full analysis set
† FAS includes all subjects randomized.
‡ Responder was defined as a patient with IGA 0 or 1 (“clear” or “almost clear”).1
§ Patients who received rescue treatment or with missing data were considered as non-responders.1
†† At day 1, patients received 600 mg of dupilumab.1
‡‡ At day 1, patients received 400 mg (baseline weight ≥30 kg) of dupilumab.1
Disease severity and eczema severity as measured by EASI
EASI results of DUPIXENT® + TCS in the AD-1652 study at Week 16 (FAS, other outcome)1,18†
Adapted from the Product Monograph and Paller et al., 2020.1,18
* Nominal p-values.
The efficacy of DUPIXENT® + TCS in pediatric patients with moderate-to-severe AD who had participated in previous clinical trials of DUPIXENT® + TCS efficacy was assessed in an open-label extension trial (AD-1434).1
- Efficacy data from this trial suggests that the effect observed at Week 16 was consistent at Week 52.
FAS: full analysis set
† FAS includes all subjects randomized.
‡ Patients who received rescue treatment or with missing data were considered as non-responders.1
§ At day 1, patients received 600 mg of dupilumab.1
†† At day 1, patients received 400 mg (baseline weight ≥30 kg) of dupilumab.1
Pruritus severity as measured by NRS
Pruritus NRS (≥4-point improvement) data from baseline to Week 16 in the AD-1652 study (FAS, other outcome)1,18†
Adapted from the Product Monograph and Paller et al., 2020.1,18
* Nominal p-values.
A greater proportion of patients randomized to DUPIXENT® + TCS achieved an improvement in the peak pruritus NRS compared to placebo + TCS (defined as ≥4-point improvement at Week 4).1
LS: least squares; FAS: full analysis set; SE: standard error
† FAS includes all subjects randomized.1
‡ Patients who received rescue treatment or with missing data were considered as non-responders.1
§ At day 1, patients received 600 mg of dupilumab.1
†† At day 1, patients received 400 mg (baseline weight ≥30 kg) of dupilumab.1
Favourable changes observed in patient-reported outcomes – CDLQI and POEM
CDLQI - LS mean change from baseline to Week 16 in the AD-1652 study (FAS, +/- SE, secondary endpoint)1,18†
Adapted from the Product Monograph and Paller et al., 2020.1,18
* Nominal p-values.
POEM - LS mean change from baseline to Week 16 in the AD-1652 study (FAS, +/- SE, secondary endpoint)1,18†
Adapted from the Product Monograph and Paller et al., 2020.1,18
* Nominal p-values.
In subjects receiving DUPIXENT®, favourable changes were observed with respect to patient-reported symptoms, the impact of AD on sleep and health-related quality of life as measured by POEM and CDLQI scores at 16 weeks compared to placebo.1
LS: least squares; FAS: full analysis set; SE: standard error
† FAS includes all subjects randomized.1
‡ At day 1, patients received 600 mg of dupilumab.1
§ At day 1, patients received 400 mg (baseline weight ≥30 kg) of dupilumab.1
Children’s Dermatology Life Quality Index (CDLQI)
The CDLQI questionnaire measures the impact of skin disease on the life of a child over the course of one week, using accessible language. The patients must answer the following 10 questions using the multiple-choice answers provided:17
© Children’s Dermatology Life Quality Index. M S Lewis-Jones, A Y Finlay, May 1993.
Instructions
Step 1:
Patients complete the 10 questions, with each question scored on a 4-point scale:17
0=not at all; 1=only a little; 2=quite a lot; 3=very much; 0=question unanswered; 3=“prevented school” answer from question 7
Step 2:
Scores are summed to obtain a final score ranging from 0 to 30, where higher scores indicate a greater impairment of quality of life.18
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00:11.247
Hey, I’m Julie. Thanks for watching.
00:12.929
Today, I’m going to show you how to properly self-inject a dose of DUPIXENT® (dupilumab) using the single-dose pre-filled pen.
00:21.267
Since you’ve already learned how to self-inject with your health care provider, I’ll be here to guide you through your first at-home experience.
00:29.112
First thing we’ll go over is, what supplies to gather, how to prep the injection area, and how to inject the dose and discard your single-dose pre-filled pen.
00:41.166
If you haven’t yet read the instructions for use, located in your DUPIXENT® treatment packaging, pause the video and take a look.
00:48.425
It has step-by-step instructions, which I will go through with you today. It is important to read all the instructions carefully before using the pre-filled pen.
00:57.908
Let’s take a closer look at the pre-filled pen.
01:01.631
I found it helpful to review the different parts of the pre-filled pen like the cap, the window, and the needle cover before handling the pre-filled pen itself.
01:20.884
OK, it’s time for me to take my DUPIXENT® injection. Feel free to watch me and follow along as I self-inject.
01:28.929
Depending on your dose, your box of DUPIXENT® may be a different colour. This is the box for the 300 mg dose.
01:37.192
Before we start, here are some guidelines.
01:40.918
Keep the pre-filled pen and all medicines out of the reach of children.
01:46.047
Keep unused pre-filled pens in the original carton and store in the refrigerator between 2ºC to 8ºC, or 36º to 46ºF.
01:57.871
To begin, take your medication out of the refrigerator.
02:04.427
Take one pen out of the packaging by holding the middle of the pen body.
02:09.596
Now, let’s check the label on the pen to ensure that the medication and dosage strength are correct, and the expiration date has not passed.
02:18.156
Do not use the pen if the expiration date has passed. If the dosage strength or expiration date isn’t right, contact your pharmacy.
02:28.771
Next, take a look at the medicine through the viewing window.
02:32.624
The liquid inside should be clear and colorless to pale yellow. You may see an air bubble. This is totally normal.
02:41.628
Do not inject DUPIXENT® if the liquid inside is discoloured, cloudy, or contains visible flakes or particles.
02:48.848
Do not use the pre-filled pen if the window is solid yellow.
02:54.684
Do not use the pre-filled pen if it has been damaged.
02:59.333
Do not use the pre-filled pen if the cap is missing or not securely attached.
03:08.318
If you have any questions about whether the pen is ok to use, please call the Freedom support program, or your healthcare provider.
03:17.080
If you have an unused pre-filled pen, return it to the refrigerator in the original carton to protect it from the light.
03:27.670
Lay the pre-filled pen on a flat surface and let it naturally warm to room temperature.
03:37.104
Do not freeze or heat the pre-filled pen.
03:40.875
Do not put the pre-filled pen into direct sunlight.
03:45.793
Throw away any pre-filled pen that has been left at room temperature for more than 14 days.
03:51.907
On that note, if you ever need to remove a DUPIXENT® carton from the refrigerator,
03:56.173
it’s a good idea to write down the date of removal in the space provided on the outer carton, so that you can remember to use DUPIXENT® within 14 days.
04:08.289
Do not shake the pre-filled pen at any time.
04:15.033
As the pen warms up, let’s gather some additional materials you’ll need to self-inject.
04:20.955
You’ll need a cotton ball or gauze, an alcohol wipe and a puncture resistant disposal container.
04:30.776
If you don’t have a puncture resistant disposal container, call your pharmacy,
04:34.426
the Freedom support program or your healthcare provider to request a puncture-resistant disposal container.
04:43.128
Now, take your supplies to an area where you can sit comfortably.
04:48.276
I prefer the comfort of my living room couch. You might prefer the bathroom or your bedroom for privacy.
04:56.142
We’re almost ready to inject DUPIXENT®.
04:59.621
First, let’s wash our hands thoroughly with soap and water.
05:04.514
Next, let’s choose an injection site.
05:07.613
Both the stomach and thigh are acceptable
05:10.173
except for the 5 centimeters or 2 inches around your belly button.
05:15.809
If a caregiver gives you the injection, the outer area of the upper arm is also an option.
05:22.267
The person giving the injection should follow the same preparation procedure.
05:28.667
Be sure to choose a different site each time you inject DUPIXENT®.
05:34.164
Do not inject through clothes.
05:36.966
Do not inject into skin that is tender, damaged, bruised or scarred.
05:49.999
Now clean your skin with the alcohol wipe.
05:58.516
Do not touch your skin again or blow on it before the injection.
06:03.256
Let your skin dry before injection.
06:08.575
Pick up the pen by holding the middle of the pen body, with the needle pointing away from you.
06:15.515
With the other hand, pull the cap straight off.
06:19.830
Once you have removed the cap, do not put it back on.
06:23.801
Do not twist the cap off.
06:26.086
Do not remove it until you are ready to inject.
06:30.582
Do not press or touch the needle cover with your fingers.
06:35.043
Do not try to put the cap back on once you’ve removed it.
06:39.838
Inject the medicine right away after removing the cap.
06:43.628
Place the yellow needle cover on your skin at approximately a 90-degree angle.
06:51.182
Make sure you can see the injector window.
06:56.006
Press down and hold the pen firmly against your skin until you can no longer see the Needle Cover.
07:03.110
There may be a “click” when the injection starts.
07:06.303
As you hold the pen firmly against your skin, the injector window will start to turn yellow.
07:13.494
The injection can take up to 20 seconds.
07:16.489
You may hear a second click.
07:20.790
Check that the entire window has turned to yellow before removing the pen.
07:25.350
Slowly count to 5, and then lift the pen up straight off the skin.
07:30.816
And that’s it! You’re done.
07:35.014
If the window does not turn fully yellow,
07:37.817
remove the pen and call your healthcare provider or Freedom support program nurse.
07:43.991
Do not give yourself a second dose without speaking to your healthcare provider.
07:50.903
Lightly press a cotton ball or gauze on the injection site if you see any blood.
07:56.338
You can also cover the site with a bandage.
08:00.517
Do not rub your skin after the injection.
08:04.116
Be sure to put the used pen and its cap into a puncture resistant disposal container right away after use.
08:15.817
Do not re-use the pre-filled pen.
08:19.294
Do not dispose of pre-filled pens in your household trash.
08:24.259
Do not recycle your used puncture resistant container.
08:29.282
Follow your local guidelines and ask your pharmacy or healthcare provider for the appropriate way to dispose of your used pen.
08:39.909
Be sure to keep track of your injection date and site.
08:44.411
Thank you for joining me today.
08:46.416
Remember you can rewatch this video as often as you like to refresh your memory.
08:51.753
Contact your healthcare provider or the Freedom support program with any questions or concerns.
00:07.155
Hi there, I’m Laura. Today I’m going to show you how to properly self-inject a dose of DUPIXENT®.
00:13.539
You’ve already learned how to self-inject with your health care provider. I’m here to guide your first at-home experience.
00:21.282
I’ll show what supplies to gather, how to prep the injection area, and how to inject the dose and discard your used syringe.
00:31.423
If you haven’t yet read the instructions for use, located in your treatment packaging, pause the video and take a look. It has complete step-by step instructions that I’ll show you today.
00:44.283
It is important to read all of the instructions carefully before using the syringe.
00:49.460
There are a few simple guidelines I’d like to tell you about before we begin.
00:54.482
Keep DUPIXENT® out of the reach of children.
00:58.965
DUPIXENT® is stored in the refrigerator, You should never freeze it, or shake it at any time.
01:05.152
OK, let’s review what the syringe looks like.
01:11.266
I found it helpful to understand the plunger, syringe body, and needle cap before handling the syringe itself.
01:19.142
It’s time for me to take my DUPIXENT® injection. Feel free to watch me and follow along as I self-inject.
01:26.809
Take your medication out of the refrigerator.
01:30.654
Remove the syringe from its package by holding the middle of the syringe body.
01:36.921
If the syringe accidentally drops on a hard surface or is damaged, it should not be used.
01:43.577
Keep the needle cap on until you are ready to inject. It’s also a good idea not to touch the plunger until you are ready to inject, or pull back on the plunger at any time.
01:55.923
If you have an unused syringe still in the package, return it to the refrigerator in the original carton to protect it from light.
02:04.544
Now that the syringe is out of its package, check the label on the syringe body to make sure it says DUPIXENT®,
02:11.996
and to make sure the expiration date has not passed. If it isn’t right, contact your pharmacy and they will help you.
02:19.671
You may see an air bubble within the medication. This is normal. The liquid inside should be clear and colorless to pale yellow.
02:29.842
You should not use the syringe if the liquid is discoloured, cloudy, or if it contains flakes or particles
02:36.081
Lay the syringe on a flat surface and let it warm to room temperature naturally. Make sure you do not heat the syringe or put it into direct sunlight to warm it up.
02:46.695
It takes about 45 minutes for the syringe to warm up naturally.
02:52.232
Once it has been warmed up to room temperature, remember that you need to use DUPIXENT® within 14 days.
02:58.363
Throw away any syringe left at room temperature for longer than 14 days because it won’t be good anymore.
03:05.489
On that note, if you ever need to remove the DUPIXENT® carton from the refrigerator, it’s a good idea to write down the date of removal in the space provided on the outer carton so you can remember to use DUPIXENT® within 14 days.
03:20.588
While you wait, gather the additional supplies necessary to self-inject.
03:24.480
You need 1 cotton ball or gauze, 1 alcohol wipe, and a puncture resistant sharps disposal container.
03:32.606
Now take your supplies to an area where you can sit comfortably.
03:37.986
When you are ready to get started, wash your hands thoroughly.
03:47.044
Choose your injection site. The stomach and thigh are acceptable except for the 5 centimeters around your belly button.
03:54.044
If somebody else gives you the injection, the outer area of the upper arm is also an option. The person giving the injection should follow the same preparation procedure.
04:04.947
Be sure to choose a different site each time you inject DUPIXENT®.
04:08.722
When you choose your injection site, make sure you do not inject through clothes or inject into skin that is tender, damaged, or is bruised or scarred.
04:20.237
Clean your skin with the alcohol wipe.
04:24.067
Let your skin dry naturally before injecting.
04:27.540
Do not touch your skin again or blow on it before the injection.
04:36.768
Hold the syringe in the middle of the syringe body with the needle pointing away from you and carefully pull off the needle cap.
04:45.769
If you notice the needle cap is missing or not securely attached, or if the needle is damaged, you should not use the syringe.
04:53.010
Once you have removed the needle cap, do not try to put it back on or touch the needle.
04:59.617
Inject the medicine right away after removing the needle cap.
05:05.937
Pinch your skin at the injection site. Pinching your skin helps the medicine go into a fatty layer below the skin and not into the muscle.
05:13.337
Take a deep breath and continue to pinch as you insert the needle completely at about a 45 degree angle.
05:21.837
Relax your pinch. Push the plunger down slowly and steadily as far as it will go until the syringe is empty. It’s normal to feel a bit of resistance.
05:33.019
To get the needle out of your skin, keep pressing the plunger down and remove the needle from your skin at the same angle it was inserted.
05:42.206
Once the needle is out of the skin, lift your thumb to retract the needle up into the needle shield.
05:47.614
Throw out the syringe and the needle cap in the sharps disposal container right away. You should not try to put the cap back on, and the syringe should not be reused.
05:58.775
Follow your local guidelines or ask your healthcare provider for the appropriate way to dispose of the container once it is full.
06:05.951
Do not dispose in household trash.
06:09.976
If you see any blood at the injection site, gently press it with your cotton ball or gauze.
06:14.950
You should not rub your skin after the injection.
06:18.617
Be sure to keep track of your injection date and site.
06:21.900
It is also recommended to rotate the injection site with each injection.
06:26.819
Thank you for joining me today.
06:29.148
Remember you can always watch this video as often as you like to refresh your memory.
06:34.230
If you have any questions you can call the Freedom Program at 1-844-216-1181
06:42.289
to speak with your dedicated case manager or speak with your health care professional.
Coming Soon
00:11.099
Hi there. Thanks for watching.
00:13.203
Today we’re going to show you how to properly inject a dose of DUPIXENT® (dupilumab) using the single-dose pre-filled pen.
00:21.320
I know you’ve already learned how to give an injection with your healthcare provider.
00:26.446
We are here to guide you through your first at-home experience.
00:30.459
First thing we’ll go over is what supplies to gather, how to prep the injection area,
00:35.239
how to inject the dose and discard your single-dose pre-filled pen.
00:41.728
If you haven’t yet read the instructions for use, located in your DUPIXENT® treatment package, pause the video and take a look.
00:49.194
It has step-by-step instructions, which I will go through with you today.
00:54.113
It’s important to read all of the instructions carefully before using the pre-filled pen.
01:00.322
Let’s take a closer look at the pre-filled pen.
01:03.571
I found it helpful to review the different parts of the pre-filled pen
01:07.812
like the cap, the window, and the needle cover before handling the pre-filled pen itself.
01:22.079
OK, it’s time for your DUPIXENT® injection. Are you ready?
01:24.837
Yeah.
01:26.087
Feel free to watch us and follow along as I give an injection.
01:30.625
Depending on your dose, your box of DUPIXENT® may be a different colour. This is the box for the 300 mg dose.
01:39.022
Before we start, here are some guidelines.
01:42.652
Keep the pre-filled pen and all medicines out of the reach of children.
01:47.863
Keep unused pre-filled pens in the original carton
01:50.285
and store in the refrigerator between 2ºC to 8ºC, or 36º to 46ºF.
01:59.578
To begin, take your medication out of the refrigerator.
02:06.126
Take one pen out of the packaging by holding the middle of the pen body.
02:11.240
Now, let’s check the label on the pen to ensure that the medication and dosage strength are correct,
02:16.284
and the expiration date has not passed.
02:19.854
Do not use the pen if the expiration date has passed.
02:23.802
If the dosage strength or expiration date isn’t right, contact your pharmacy.
02:30.416
Next take a look at the medicine through the viewing window.
02:34.222
The liquid inside should be clear and colorless to pale yellow.
02:38.955
You may see an air bubble. This is totally normal.
02:43.472
Do not inject DUPIXENT® if the liquid inside is discoloured, cloudy, or contains visible flakes or particles.
02:51.568
Do not use the pre-filled pen if the window is solid yellow.
02:56.526
Do not use the pre-filled pen if it’s been damaged.
03:00.763
Do not use the pre-filled pen if the cap is missing or not securely attached.
03:10.114
If you have any questions about whether the pen is ok to use, please call the Freedom support program, or your healthcare provider.
03:19.205
If you have an unused pre-filled pen, return it to the refrigerator in the original carton to protect it from the light.
03:29.408
Lay the pre-filled pen on a flat surface and let it naturally warm to room temperature.
03:38.790
Do not freeze or heat the pre-filled pen.
03:42.549
Do not put the pre-filled pen into direct sunlight.
03:47.505
Throw away any pre-filled pen that’s been left at room temperature for more than 14 days.
03:53.575
On that note, if you ever need to remove a DUPIXENT® carton from the refrigerator,
03:57.713
it’s a good idea to write down the date of removal in the space provided on the outer carton,
04:03.397
so that you can remember to use DUPIXENT® within 14 days.
04:10.005
Do not shake the pre-filled pen at any time.
04:16.330
As the pen warms up, let’s gather some additional materials you’ll need for the injection.
04:22.716
You’ll need a cotton ball or gauze, an alcohol wipe, and a puncture resistant disposal container.
04:32.495
If you don’t have a puncture resistant disposal container, call your pharmacy,
04:36.282
the Freedom support program,
04:38.060
or your healthcare provider to request a puncture-resistant disposal container.
04:44.998
Now take your supplies to an area where you and your child can sit comfortably.
04:50.239
I prefer the comfort of our living room couch. You might prefer the bathroom or your bedroom for privacy.
04:58.075
We’re almost ready to inject DUPIXENT®.
05:00.106
First, let’s wash our hands thoroughly with soap and water.
05:06.146
Next, let’s choose an injection site.
05:09.340
Both the stomach and thigh are acceptable except for the 5 centimeters or 2 inches around the belly button.
05:16.533
The outer area of the upper arm is also an option since you are giving the injection to someone,
05:21.840
but not if you are self-injecting.
05:26.483
Be sure to choose a different site each time you inject DUPIXENT®.
05:32.141
Do not inject through clothes.
05:33.681
Do not inject into skin that is tender, damaged, bruised or scarred.
05:43.013
Now clean the skin with the alcohol wipe.
05:53.104
Do not touch the injection site again or blow on it before the injection.
05:58.038
Let your skin dry before injection.
06:02.582
Pick up the pen by holding the middle of the pen body, with the needle pointing away from you.
06:08.386
With the other hand, pull the cap straight off.
06:12.610
Once you’ve removed the cap, do not put it back on.
06:16.612
Do not twist the cap off.
06:18.926
Do not remove the cap until you are ready to inject.
06:22.496
Do not press or touch the needle cover with your fingers. The needle is inside.
06:27.119
Do not try to put the cap back on once you’ve removed it.
06:32.561
Inject the medicine right away after removing the cap.
06:36.727
Place the yellow needle cover on the skin at approximately a 90-degree angle.
06:41.749
Make sure you can see the injector window.
06:47.271
Press down and hold the pen firmly against the skin until you can no longer see the Needle Cover.
06:54.219
There may be a “click” when the injection starts.
06:56.638
As you hold the pen firmly against the skin, the injector window will start to turn yellow.
07:04.446
The injection can take up to 20 seconds.
07:07.559
You may hear a second click.
07:10.770
Check that the entire Window has turned to yellow before removing the pen.
07:15.437
Slowly count to 5, and then lift the pen up straight off the skin.
07:21.051
That’s it! You’re done.
07:24.983
If the Window does not turn fully Yellow,
07:27.366
remove the pen and call your healthcare provider or Freedom support program nurse.
07:33.784
Do not give a second dose without speaking to your healthcare provider.
07:40.799
Lightly press a cotton ball or gauze on the injection site if you see any blood.
07:46.617
You can also cover the site with a bandage.
07:50.030
Your child should not rub their skin after the injection.
07:54.049
Be sure to put the used pen and its cap into a puncture-resistant disposal container
07:58.910
right away after use.
08:02.283
Do not re-use the pre-filled pen.
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Do not dispose of pre-filled pens in your household trash.
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Do not recycle your used puncture resistant container.
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Follow your local guidelines and ask your pharmacy or healthcare provider for the appropriate way to dispose of your used pen.
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Be sure to keep track of the injection date and site.
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Thank you for joining us today.
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Remember you can rewatch this video as often as you like to refresh your memory.
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Contact your healthcare provider or the Freedom support program with any questions or concerns.
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Since you’re watching this video, I know you’ve already learned how to give an injection with your healthcare provider.
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We’re just here to help guide you through your first at-home experience.
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If you haven’t yet read the instructions for use, located in your treatment packaging, pause the video and take a look.
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It has step-by-step instructions, which I will go through with you today.
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And if you have any questions along the way, don’t hesitate to reach out to your healthcare provider.
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OK it's time for your DUPIXENT® injection. Are you ready?
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Yes
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Feel free to watch us and follow along as I give an injection.
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To begin, take your medication out of the refrigerator. Do not freeze the DUPIXENT® syringe.
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Depending on your dose, your box of DUPIXENT® may be a different colour.
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This is the box for the 300 mg dose.
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Remove the syringe by holding the middle of the syringe body.
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A few things to remember:
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Do not use the syringe if it has been dropped on a hard surface or is damaged.
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Do not pull off the needle cap or touch the plunger rod until you are ready to inject.
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Do not pull back on the plunger rod at any time.
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Keep DUPIXENT® syringes and all medicines out of the reach of children.
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If you have any questions about whether the syringe is ok to use,
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please call the Freedom support program, or your healthcare provider.
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Keep unused pre-filled syringes in the original carton and store in refrigerator between 2ºC to 8ºC, or 36º to 46ºF.
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Your DUPIXENT® prefilled syringe may appear different from what you see in this video based on the prescribed dose.
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If you have questions about the dosage prescribed, please contact your healthcare provider.
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OK, now it’s time to check the label to make sure the medication and dosage are correct
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and the expiration date is not passed.
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If it isn’t right, contact your pharmacy.
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Now look at the medicine through the viewing window on the DUPIXENT® syringe.
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The liquid inside should be clear and colorless to pale yellow.
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You may see an air bubble. This is normal.
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Do not try and get rid of any air bubbles.
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Do not use the syringe if the liquid is discolored or cloudy, or if it contains visible flakes or particles.
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Throw away and dispose of the used DUPIXENT® single-dose prefilled syringe right away after use.
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Lay the syringe on a flat surface and let it naturally warm to room temperature.
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Here are a few more things to remember:
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do not heat the syringe. Do not put the syringe into direct sunlight.
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Do not keep DUPIXENT® at room temperature for more than 14 days.
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Write down the date that you removed it from the fridge in the space provided on the outer carton,
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and throw away any syringe that has been left at room temperature for longer than 14 days.
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Do not shake the syringe.
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While you wait, gather the additional necessary materials.
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You need one cotton ball or gauze, one alcohol wipe, and a puncture-resistant sharps disposal container.
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When you are ready to get started, wash your hands thoroughly.
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Now, take your supplies to an area where you can sit comfortably.
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Choose your injection site. Both the stomach and thigh are acceptable,
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except for the two inches around the belly button.
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The outer area of the upper arm is also an option since you are giving the injection to someone,
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but not if you are self-injecting.
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Be sure to choose a different site each time you inject DUPIXENT®.
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Do not inject through clothes.
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Do not inject into skin that is tender, damaged, bruised, or scarred.
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OK, now clean the skin with the alcohol wipe.
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Do not touch the injection site again or blow in it before the injection.
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Let the skin dry before injection.
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Once the skin is dry, hold the DUPIXENT® syringe in the middle of the syringe body with the needle pointing away from you
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and carefully remove the cap from the syringe by pulling it off.
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Do not use if the needle cap is missing or not securely attached.
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Do not put the needle cap back on.
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Do not touch the needle
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Inject the medicine right away after removing the needle cap.
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Pinch a fold of skin at the injection site.
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Take a deep breath.
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Continue to pinch as you insert the needle completely at about a 45-degree angle.
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Relax your pinch. Push the plunger down slowly and steadily as far as it will go until the syringe is empty.
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You will feel some resistance. This is normal.
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Lift your thumb to release the plunger rod until the needle is covered by the needle shield
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and then remove the syringe from the injection site.
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Lightly press a cotton ball or gauze on the injection site if you see any blood.
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Do not put the needle cap back on and do not rub the skin after the injection.
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OK, now put the used DUPIXENT® syringe and cap in a sharps disposal container right away after use.
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Do not put DUPIXENT® syringes in your household trash.
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Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full.
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Do not recycle your used sharps disposal container and do not reuse the syringe.
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Finally, always be sure to keep track of the injection date and site.
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Thank you for joining us today.
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Remember you can rewatch this video as often as you like to refresh your memory.
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Contact your healthcare provider or the Freedom Support Program with any questions or concerns.
This DUPIXENT (dupilumab injection) website is for Canadian healthcare professionals only.
Please select your province and enter your medical license number to access the website.